Endocrine Abstracts

Abnormal uterine bleeding (AUB) is a debilitating symptom that affects up to one in three women at some point in their reproductive lives. It may result in anaemia that necessitates blood transfusion and has a significant negative impact on quality of life. In addition, AUB has a detrimental economic impact on those who experience it, health services and the wider economy. A number of medical treatment options for AUB are curre...

Introduction: The human endometrium has a remarkable capacity for repeated repair following the inflammation of menstruation. This occurs without scarring or loss of function but mechanisms involved remain undefined. Aberrations in endometrial repair may lead to pathology such as heavy menstrual bleeding (HMB). The transforming growth factor-β superfamily has been implicated in efficient wound repair and has a potential role in menstrual repair. Downstream of TGF-β, ...

Heavy menstrual bleeding (HMB) is common and debilitating but it remains a taboo subject. Hence its cause remains undefined, resulting in non-specific hormone therapies with intolerable side effects.Over 70 years ago it was proposed that progesterone withdrawal caused intense vasoconstriction and a transient endometrial hypoxia that resulted in menstruation. Subsequent research confirmed that inflammation initiated menses and disputed the role of hypoxia...

Heavy menstrual bleeding (HMB) is common and debilitating but it remains a taboo subject. Hence its cause remains undefined, resulting in non-specific hormone therapies with intolerable side effects.Over 70 years ago it was proposed that progesterone withdrawal caused intense vasoconstriction and a transient endometrial hypoxia that resulted in menstruation. Subsequent research confirmed that inflammation initiated menses and disputed the role of hypoxia...

Women with COVID-19 and Long COVID (symptoms >4 weeks) have reported AUB. We investigated (i) the association between COVID-19/Long COVID and AUB and (ii) ovarian sex hormones across the menstrual cycle in women with Long COVID. Two studies were completed with ethical approvals and consent. Firstly, a retrospective online survey ‘The Covid-19 Pandemic and Women’s Reproductive Health’ was conducted March-May 2021 with UK participants >18 years old (n<...